Problems in Homebrew tap Brewsci/bio

Repository Project Package name Maintainer Problem
Homebrew tap Brewsci/bio fraggenescan fraggenescan - Homepage link "https://github.com/COL-IU/FragGeneScan" is dead (HTTP error 404) for more than a month.
Homebrew tap Brewsci/bio humann2 humann2 - Homepage link "https://huttenhower.sph.harvard.edu/humann" is dead (SSL certificate has expired) for more than a month.
Homebrew tap Brewsci/bio metaphlan metaphlan - Homepage link "https://huttenhower.sph.harvard.edu/metaphlan" is dead (SSL certificate has expired) for more than a month.
Homebrew tap Brewsci/bio mp-est mp-est - Homepage link "https://faculty.franklin.uga.edu/lliu/content/mp-est" is dead (HTTP error 404) for more than a month.
Homebrew tap Brewsci/bio realphy realphy - Homepage link "https://realphy.unibas.ch/fcgi/realphy" is dead (HTTP error 404) for more than a month.